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เทวิน เทนคำเนาว์

ผศ.ดร.ทนพ.

Asst.Prof. Tewin Tencomnao, Ph.D.

ผศ.ดร.ทนพ. เทวิน เทนคำเนาว์

Tewin Tencomnao

Asst.Prof.

Biosensors and Medical Instrumentation

Abbreviated Name: -

Main Affiliation: Age-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences (AHSCU)

Email: tewin.t@chula.ac.th

Phone Number: -

Office: -

Abbreviated Name: -

Main Affiliation: Age-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences (AHSCU)

Email: tewin.t@chula.ac.th

Phone Number: -

Office: -

อักษรย่อ: -

หน่วยงานหลัก: หน่วยปฏิบัติการวิจัยด้านภาวะอักเสบและความเสื่อมที่เกี่ยวข้องกับความชรา ภาควิชาเคมีคลินิก คณะสหเวชศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย

อีเมล: tewin.t@chula.ac.th

เบอร์โทรศัพท์: -

ห้องทำงาน: -

คุณวุฒิ:

  • Ph.D. (Biochemistry and Molecular Biophysics) Virginia Commonwealth University, พ.ศ. 2544

  • วท.บ. (เทคนิคการแพทย์) จุฬาลงกรณ์มหาวิทยาลัย, พ.ศ. 2536

Education:

  • Ph.D. (Biochemistry and Molecular Biophysics) Virginia Commonwealth University, 2001

  • B.Sc. (Medical Technology) Chulalongkorn University, 1993

Review Article

  • Brimson JM, Prasanth MI, Malar DS, Thitilertdecha P, Kabra A, Tencomnao T, Prasansuklab A. Plant Polyphenols for Aging Health: Implication from Their Autophagy Modulating Properties in Age-Associated Diseases. Pharmaceuticals. 2021 Sep 27;14(10):982.

  • Brimson JM, Prasanth MI, Malar DS, Brimson S, Thitilertdecha P, Tencomnao T. Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy. Expert Opin Ther Targets. 2021 Jul 15:1-15.

  • Prasanth MI,Tencomnao T, Brimson JM. The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke. Expert Opin Ther Targets. 2021 Jul 8;25(7):613-614.

  • Brimson JM, Prasanth MI, Malar DS, Sharika R, Sivamaruthi BS, Kesika P, Chaiyasut C, Tencomnao T, Prasansuklab A. Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health. Nutrients. 2021 Jun 23;13(7):2162.

  • Prasanth MI, Malar DS, Tencomnao T, Brimson JM. The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's. Expert Opin Ther Targets. 2021 May;25(5):401-414.

  • PRASANTH MI, SIVAMARUTHI BS, SUKPRASANSAP M, CHUCHAWANKUL S, TENCOMNAO T, CHAIYASUT C. Functional properties and Bioactivities of Cleistocalyx nervosum var. paniala berry plant: a review. Food Science and Technology. April 2020. 2020(AHEAD). https://doi.org/10.1590/fst.30719.

  • Prasansuklab A, Theerasri A, Rangsinth P, Sillapachaiyaporn C, Chuchawankul S, Tencomnao T. Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection. J Tradit Complement Med. 2021 Mar;11(2):144-157.

  • Prasansuklab A, Brimson JM, Tencomnao T. Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect. Journal of Traditional and Complementary Medicine. 2020 Mar 20;10(3):301-308. Pubmed.

  • Malar DS, Prasanth MI, Brimson JM, Sharika R, Sivamaruthi BS, Chaiyasut C,Tencomnao T. Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson’s Disease: A Review. Molecules. 2020 Jan;25(17):3926. ISI, Pubmed.

  • Brimson JM, Onlamoon N, Tencomnao T, Thitilertdecha P. Clerodendrum petasites S. Moore: The therapeutic potential of phytochemicals, hispidulin, vanillic acid, verbascoside, and apigenin. Biomedicine & Pharmacotherapy. 2019 Oct 1;118:109319. ISI, Pubmed.

  • Prasanth MI, Sivamaruthi BS, Chaiyasut C, Tencomnao T. A review of the role of green tea (Camellia sinensis) in antiphotoaging, stress resistance, neuroprotection, and autophagy. Nutrients. 2019 Feb;11(2):474. ISI, Pubmed.

Journal Article

  • Vongthip W, Sillapachaiyaporn C, Kim KW, Sukprasansap M,Tencomnao T. Thunbergia laurifolia Leaf Extract Inhibits Glutamate-Induced Neurotoxicity and Cell Death through Mitophagy Signaling. Antioxidants. 2021 Oct 25;10(11):1678.

  • Sillapachaiyaporn C, Rangsinth P, Nilkhet S, Ung AT, Chuchawankul S, Tencomnao T. Neuroprotective Effects against Glutamate-Induced HT-22 Hippocampal Cell Damage and Caenorhabditis elegans Lifespan/Healthspan Enhancing Activity of Auricularia polytricha Mushroom Extracts. Pharmaceuticals. 2021 Sep 29;14(10):1001.

  • Malar DS, Prasanth MI, Brimson JM, Verma K, Prasansuklab A, Tencomnao T. Hibiscus sabdariffa extract protects HT-22 cells from glutamate-induced neurodegeneration by upregulating glutamate transporters and exerts lifespan extension in C. elegans via DAF-16 mediated pathway. Nutrition and Healthy Aging. 2021 Sep 10.

  • Rangsinth P, Duangjan C, Sillapachaiyaporn C, Isidoro C, Prasansuklab A, Tencomnao T. Caesalpinia mimosoides Leaf Extract Promotes Neurite Outgrowth and Inhibits BACE1 Activity in Mutant APP-Overexpressing Neuronal Neuro2a Cells. Pharmaceuticals. 2021 Sep 4;14(9):901.

  • Duangjan C, Rangsinth P, Zhang S, Gu X, Wink M, Tencomnao T. Neuroprotective Effects of Glochidion zeylanicum Leaf Extract against H2O2/Glutamate-Induced Toxicity in Cultured Neuronal Cells and Aβ-Induced Toxicity in Caenorhabditis elegans. Biology. 2021 Aug 6;10(8):800.

  • Pattarachotanant N, Prasansuklab A, Tencomnao T. Momordica charantia L. Extract Protects Hippocampal Neuronal Cells against PAHs-Induced Neurotoxicity: Possible Active Constituents Include Stigmasterol and Vitamin E. Nutrients. 2021 Jul 10;13(7):2368.

  • Duangjan C, Rangsinth P, Zhang S, Gu X, Wink M, Tencomnao T. Vitis Vinifera Leaf Extract Protects Against Glutamate-Induced Oxidative Toxicity in HT22 Hippocampal Neuronal Cells and Increases Stress Resistance Properties in Caenorhabditis Elegans. Front Nutr. 2021 Jun 11;8:634100.

  • Prasanth MI, Brimson JM, Malar DS, Prasansuklab A, Tencomnao T. Streblus asper Lour. exerts MAPK and SKN-1 mediated anti-aging, anti-photoaging activities and imparts neuroprotection by ameliorating Aβ in Caenorhabditis elegans. Nutrition and Healthy Aging. 2021 Apr 29;6(3):211-227.

  • Duangjan C, Rangsinth P, Zhang S, Wink M, Tencomnao T.Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein. Front Pharmacol. 2021 Apr 23;12:627738.

  • Tonsomboon A, Prasanth MI, Plaingam W, Tencomnao T. Kaempferia parviflora Rhizome Extract Inhibits Glutamate-Induced Toxicity in HT-22 Mouse Hippocampal Neuronal Cells and Extends Longevity in Caenorhabditis elegans. Biology (Basel). 2021 Mar 26;10(4):264. doi: 10.3390/biology10040264. PMID: 33810282; PMCID: PMC8066628.

  • Sulistiyani E, Brimson JM, Chansaenroj A, Sariya L, Urkasemsin G, Oonsiri S, Tencomnao T, Vacharaksa A, Chaisuparat R, Ferreira JN. Epigallocatechin-3-Gallate Protects Pro-Acinar Epithelia Against Salivary Gland Radiation Injury. Int J Mol Sci. 2021 Mar 19;22(6):3162.

  • Kittimongkolsuk P, Roxo M, Li H, Chuchawankul S, Wink M, Tencomnao T. Extracts of the Tiger Milk Mushroom (Lignosus rhinocerus) Enhance Stress Resistance and Extend Lifespan in Caenorhabditis elegans via the DAF-16/FoxO Signaling Pathway. Pharmaceuticals (Basel). 2021 Jan 27;14(2):93.

  • Brimson JM, Prasanth MI, Isidoro C, Sukprasansap M, Tencomnao T. Cleistocalyx nervosum var. paniala seed extracts exhibit sigma-1 antagonist sensitive neuroprotective effects in PC12 cells and protects C. elegans from stress via the SKN-1/NRF-2 pathway. Nutrition and Healthy Aging 2021 Jan 15;6(2):131-146.

  • Brimson JM, Brimson S, Prasanth MI, Thitilertdecha P, Malar DS, Tencomnao T. The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data. Sci Rep. 2021 Jan 12; 11:596.

  • Thongkorn S, Kanlayaprasit S, Panjabud P, Saeliw T, Jantheang T, Kasitipradit K, Sarobol S, Jindatip D, Hu VW, Tencomnao T, Kikkawa T, Sato T, Osumi N, Sarachana T. Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions. Sci Rep. 2021 Jan 13;11(1):1241.

  • Kittimongkolsuk P, Pattarachotanant N, Chuchawankul S, Wink M, Tencomnao T.Neuroprotective Effects of Extracts from Tiger Milk Mushroom Lignosus rhinocerus Against Glutamate-Induced Toxicity in HT22 Hippocampal Neuronal Cells and Neurodegenerative Diseases in Caenorhabditis elegans. Biology (Basel). 2021 Jan 5;10(1):30.

  • Rangsinth P, Sillapachaiyaporn C, Nilkhet S,Tencomnao T, Ung AT, Chuchawankul S. Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: An in silico approach. J Tradit Complement Med. 2021 Jan 4. doi: 10.1016/j.jtcme.2020.12.002. Epub ahead of print.

  • Lomphithak T, Choksi S, Mutirangura A, Tohtong R, Tencomnao T, Usubuchi H, Unno M, Sasano H, Jitkaew S. Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma. Cell Communication and Signaling. 2020 Dec;18(1):1-20. ISI, Pubmed.

  • Pattarachotanant N, Tencomnao T. Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence. Pharmaceuticals. 2020 Oct;13(10):283. Pubmed.

  • Brimson JM, Brimson S, Chomchoei C,Tencomnao T. Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain. Expert Opinion on Therapeutic Targets.2020 Sep 1:1-20. Pubmed.

  • Brimson JM, Prasanth MI, Plaingam W,Tencomnao T. Bacopa monnieri (L.) wettst. extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans. Journal of traditional and complementary medicine. 2020 Sep 1;10(5):460-70. Pubmed.

  • Zhang S, Duangjan C, Tencomnao T, Liu J, Lin J, Wink M. Neuroprotective effects of oolong tea extracts against glutamate-induced toxicity in cultured neuronal cells and β-amyloid-induced toxicity in Caenorhabditis elegans. Food & Function. 2020 Aug;11(9):8179-92. https://doi.org/10.1039/D0FO01072C.

  • Sukjamnong S, Thongkorn S, Kanlayaprasit S, Saeliw T, Hussem K, Warayanon W, Hu VW, Tencomnao T, Sarachana T. Prenatal exposure to bisphenol A alters the transcriptome-interactome profiles of genes associated with Alzheimer’s disease in the offspring hippocampus. Scientific Reports. 2020 Jun 11;10(1):1-5. ISI, Scopus, Pubmed.

  • Brimson JM, Akula KK, Abbas H, Ferry DR, Kulkarni SK, Russell ST, Tisdale MJ, Tencomnao T, Safrany ST. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Scientific Reports. 2020 Jun 8;10(1):1-3. ISI, Scopus, Pubmed.

  • Noiphung J, Prasanth MI, Tencomnao T, Laiwattanapaisal W. Paper-based Analytical Device for Real-time Monitoring of Egg Hatching in the Model Nematode Caenorhabditis elegans. ACS Sensors. May 2563.2020, 5, 6, 1750–1757. ISI, Pubmed.

  • Sukprasansap M, Chanvorachote P, Tencomnao T. Cyanidin-3-glucoside activates Nrf2-antioxidant response element and protects against glutamate-induced oxidative and endoplasmic reticulum stress in HT22 hippocampal neuronal cells. BMC Complementary Medicine and Therapies. (2020 Feb 11;20(1):46. ISI, Scopus, Pubmed.

  • Prasanth MI, Brimson JM, Chuchawankul S, Sukprasansap M, Tencomnao T. Antiaging, Stress Resistance, and Neuroprotective Efficacies of Cleistocalyx nervosum var. paniala Fruit Extracts Using Caenorhabditis elegans Model. Oxidative Medicine and Cellular Longevity. 2019 Nov 29:7024785. ISI, Pubmed.

  • Duangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T. Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine. 2019 Nov 1;64:153061. ISI, Pubmed.

  • Duangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T. Data on the effects of Glochidion zeylanicum leaf extracts in Caenorhabditis elegans. Data in brief. 2019 Oct 1; 26:104461. ISI, Pubmed.

  • Rangsinth P, Prasansuklab A, Duangjan C, Gu X, Meemon K, Wink M, Tencomnao T. Leaf extract of Caesalpinia mimosoides enhances oxidative stress resistance and prolongs lifespan in Caenorhabditis elegans. BMC Complement Altern Med. 2019 Jul 8;19(1):164. doi: 10.1186/s12906-019-2578-5. ISI, Scopus, Pubmed.

  • Duangjan C, Rangsinth P, Gu X, Wink M,Tencomnao T. Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxid Med Cell Longev. 2019 Jun 2:9012396. doi: 10.1155/ 2019/9012396. ISI, Scopus, Pubmed.

  • Pichitpunpong C, Thongkorn S, Kanlayaprasit S, Yuwattana W, Plaingam W, Sangsuthum S, Aizat WM, Baharum SN, Tencomnao T, Hu VW, Sarachana T. Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment. PloS one. 2019 Mar 28; 14(3):e0214198. ISI, Scopus, Pubmed.

  • Thongkorn S, Kanlayaprasit S, Jindatip D,Tencomnao T, Hu VW, Sarachana T. Sex differences in the effects of prenatal bisphenol A exposure on genes associated with autism spectrum disorder in the hippocampus. Scientific reports. 2019 Feb 28;9(1):3038. ISI, Scopus, Pubmed.

  • Wansawat S, Prasanth MI, Isidoro C,Tencomnao T. Mucuna pruriens seed extract promotes neurite outgrowth via ten-4 dependent and independent mechanisms in Neuro2a cells. Sains Malaysiana. 2018 Dec 1;47(12):3009-15. ISI, Scopus.

  • Bahaudin KN, Sabri S, Ramzi AB, Chor AL, Tencomnao T, Baharum SN. Current progress in production of flavonoids using systems and synthetic biology platforms. Sains Malaysiana. 2018Dec 1;47(12):3077-84. ISI, Scopus.

  • Prasansuklab A, Tencomnao T. Acanthus ebracteatus leaf extract provides neuronal cell protection against oxidative stress injury induced by glutamate. BMC complementary and alternative medicine. 2018 Dec;18(1):278. ISI, Scopus, Pubmed.

  • Prasansuklab A, Theerasri A, Payne M, Ung AT,Tencomnao T. Acid-base fractions separated from Streblus asper leaf ethanolic extract exhibited antibacterial, antioxidant, anti-acetylcholinesterase, and neuroprotective activities. BMC complementary and alternative medicine. 2018 Dec;18(1):223. ISI, Scopus, Pubmed.

  • Saeliw T, Tangsuwansri C, Thongkorn S, Chonchaiya W, Suphapeetiporn K, Mutirangura A, Tencomnao T, Hu VW, Sarachana T. Integrated genome-wide Alu methylation and transcriptome profiling analyses reveal novel epigenetic regulatory networks associated with autism spectrum disorder. Molecular autism. 2018Dec;9(1):27. ISI, Scopus, Pubmed.

  • de Silva MB, Tencomnao T. The protective effect of some Thai plants and their bioactive compounds in UV light-induced skin carcinogenesis. Journal of Photochemistry and Photobiology B: Biology. 2018 Aug 1;185:80-9. ISI, Scopus, Pubmed.

  • Brimson JM, Safrany ST, Qassam H, Tencomnao T. Dipentylammonium binds to the sigma-1 receptor and protects against glutamate toxicity, attenuates dopamine toxicity and potentiates neurite outgrowth in various cultured cell lines. Neurotoxicity research. 2018 Aug 1;34(2):263-72. ISI, Scopus, Pubmed.

  • Tangsuwansri C, Saeliw T, Thongkorn S, Chonchaiya W, Suphapeetiporn K, Mutirangura A, Tencomnao T, Hu VW, Sarachana T. Investigation of epigenetic regulatory networks associated with autism spectrum disorder (ASD) by integrated global LINE-1 methylation and gene expression profiling analyses. PloS one. 2018 Jul 23;13(7):e0201071. ISI, Scopus, Pubmed.

  • Parjo NB, Zulkifli RM, Salleh MM, Tencomnao T. Antidandruff potential of kaempheria galanga ethanolic extracts for hair cream formulation. Jurnal Teknologi. April 2561.Apr 80 (3):41-46. Scopus.

  • Ahmad R, Sahidin I, Taher M, Low C, Noor NM, Sillapachaiyaporn C, Chuchawankul S, Sarachana T, Tencomnao T, Iskandar F, Rajab NF. Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities. Scientific reports. 2018 Mar 9;8(1):4202. ISI, Scopus, Pubmed.

Proceedings

  • Nantacharoen W, Sukprasansap M, Tencomnao T. Antioxidant activity and effect of Cleistocalyx nervosum var. paniala fruit extract in mouse hippocampal neuronal HT-22 cell line. The 50thNational Graduate Research Conference. June 2020.93-100.

  • Vongthip W, Sukprasansap M, Tencomnao T. Antioxidant activity and effect of Thunbergia laurifolia leaf crude extract in mouse hippocampal neuronal HT-22 cell line. The 16th KU-KPS National Conference. December 2019. 2878-2887.

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